Schultz H, Sell A, Nørgaard-Pedersen B, Arends J
Cancer. 1978 Nov;42(5):2182-6. doi: 10.1002/1097-0142(197811)42:5<2182::aid-cncr2820420515>3.0.co;2-7.
Human alpha1-fetoprotein (AFP) and chroiongonadotropin (hCG) have been studied in 67 patients with malignant germ cell neoplasia of the testis admitted to the Radium Centre, Aarhus Municipal Hospital within an 18 month period. In 34 patients with nonseminoma, AFP was elevated in 35% of cases and hCG in 38% of cases. Nonseminoma patients who presented with or developed distant metastases showed a significantly higher incidence of elevated tumor markers than patients with local or regional disease. In patients with distant metastases monitoring of AFP and/or hCG was a most sensitive and reliable indicator of disease activity. In the management of such patients these tests are as important as clinical and x-ray examinations.
在18个月的时间里，对奥胡斯市立医院镭中心收治的67例睾丸恶性生殖细胞瘤患者的人α1-甲胎蛋白（AFP）和绒毛膜促性腺激素（hCG）进行了研究。在34例非精原细胞瘤患者中，35%的病例AFP升高，38%的病例hCG升高。出现或发生远处转移的非精原细胞瘤患者肿瘤标志物升高的发生率明显高于局部或区域疾病患者。在远处转移患者中，监测AFP和/或hCG是疾病活动最敏感和可靠的指标。在这类患者的治疗中，这些检查与临床和X线检查同样重要。
