Seabra M de L, Tufik S
Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brasil.
Physiol Behav. 1993 Nov;54(5):923-6. doi: 10.1016/0031-9384(93)90303-w.
Sodium diclofenac inhibits hyperthermia induced by paradoxical sleep deprivation (PSD), which suggests the participation of prostaglandins. The temperature of paradoxical sleep-deprived rats increased from the first to the fourth day of deprivation. This hyperthermia was blocked on the second, third, and fourth days by daily administration, twice a day, of 10 mg/kg of sodium diclofenac, a potent prostaglandin synthesis inhibitor. In the dose of 10 mg/kg, a decrease of temperature was observed only on the second and third days of PSD. These data suggest the participation of prostaglandins in modulating the increase in temperature during PSD.
双氯芬酸钠可抑制由异相睡眠剥夺（PSD）诱导的体温过高，这表明前列腺素参与其中。异相睡眠被剥夺的大鼠体温在剥夺的第一天到第四天持续升高。这种体温过高在剥夺的第二天、第三天和第四天被每天两次给予10毫克/千克双氯芬酸钠（一种有效的前列腺素合成抑制剂）所阻断。在10毫克/千克的剂量下，仅在异相睡眠剥夺的第二天和第三天观察到体温下降。这些数据表明前列腺素参与调节异相睡眠剥夺期间的体温升高。
