Landis C A, Bergmann B M, Ismail M M, Rechtschaffen A
Department of Psychiatry, University of Chicago, Illinois.
Sleep. 1992 Feb;15(1):13-20. doi: 10.1093/sleep/15.1.13.
Previous studies of total sleep deprivation (TSD) and paradoxical sleep deprivation (PSD) in the rat by the disk-over-water method have indicated that both produce changes in thermoregulation. In both kinds of deprivation, there was a progressive, large increase in heat production as indicated by measures of energy expenditure (EE). In TSD there was an initial increase in waking body temperature (Tb) followed by a later decrease; in PSD there was only a progressive decrease. The increases in heat production far in excess of heat storage indicated increased heat loss in both groups. Because the increase in Tb in TSD rats was supported by ambient temperature choices (Tch) in a thermal gradient that became progressively higher during deprivation, an increase in waking temperature setpoint (TSET) was indicated. Because the rats resorted to behavioral warming in spite of greatly increased thermogenesis, they must have had some failure to retain body heat. Prior to the present study, changes in TSET, had not been evaluated in PSD rats. Because they had not shown increases in Tb, PSD rats might not have an elevated TSET, which would indicate a functional difference between PS and nonrapid eye movement (NREM) sleep. Also, an evaluation of behavioral thermoregulation in PSD rats would clarify whether their Tb decline resulted from excessive heat loss or from a lowered TSET. To evaluate changes in heat flow and TSET, EE, Tb and Tch were measured in five PSD rats and their yoked control (PSC) rats. PSD rats showed progressive increases in EE and decreases in Tb as in the earlier PSD study; Tch rose progressively. PSC rats showed minimal changes in all three parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
先前通过水盘法对大鼠进行完全睡眠剥夺（TSD）和异相睡眠剥夺（PSD）的研究表明，这两种剥夺都会引起体温调节的变化。在这两种剥夺状态下，能量消耗（EE）测量结果显示产热都有逐渐大幅增加。在TSD中，清醒时体温（Tb）最初升高，随后下降；在PSD中，Tb仅呈逐渐下降趋势。两组产热的增加远远超过热量储存，表明热量散失增加。由于TSD大鼠Tb的升高得到了热梯度环境温度选择（Tch）的支持，且在剥夺过程中Tch逐渐升高，这表明清醒时体温设定点（TSET）升高。尽管产热大幅增加，但大鼠仍采取行为性升温措施，说明它们在保持体温方面一定存在某种障碍。在本研究之前，尚未对PSD大鼠的TSET变化进行评估。由于PSD大鼠未出现Tb升高，它们可能没有升高的TSET，这表明异相睡眠（PS）和非快速眼动（NREM）睡眠之间存在功能差异。此外，对PSD大鼠行为性体温调节的评估将阐明其Tb下降是由于热量散失过多还是TSET降低所致。为了评估热流和TSET、EE、Tb和Tch的变化，对五只PSD大鼠及其配对对照（PSC）大鼠进行了测量。与早期PSD研究一样，PSD大鼠的EE逐渐增加，Tb下降；Tch逐渐上升。PSC大鼠在这三个参数上变化极小。（摘要截选至250字）
