Freeman P R
Stat Med. 1993 Aug;12(15-16):1443-52; discussion 1453-8. doi: 10.1002/sim.4780121510.
The current widespread practice of using p-values as the main means of assessing and reporting the results of clinical trials cannot be defended. Reasons for grave concern over the present situation range from the unsatisfactory nature of p-values themselves, their very common misunderstanding by statisticians as well as by clinicians and their serious distorting influence on our perception of the very nature of clinical trials. It is argued, however, that only by fully understanding the reasons why they have become so universally popular can we hope to change opinion and introduce more sensible ways of summarizing and reporting results. Some of the ways in which this might happen are discussed.
目前将P值作为评估和报告临床试验结果的主要手段这一普遍做法是站不住脚的。对当前这种情况深感担忧的原因包括P值本身不尽人意的性质、统计学家以及临床医生对其普遍存在的误解，以及它们对我们对临床试验本质的认知产生的严重扭曲影响。然而，有人认为，只有充分理解它们变得如此普遍流行的原因，我们才有希望改变观念，并引入更合理的结果总结和报告方式。本文讨论了可能实现这一点的一些方法。
