Wondimu B, Dahllöf G, Berg U, Modéer T
Department of Pedodontics, Faculty of Odontology, Huddinge University Hospital, Karolinska Institutet, Sweden.
Scand J Dent Res. 1993 Oct;101(5):282-6. doi: 10.1111/j.1600-0722.1993.tb01121.x.
Gingival overgrowth was assessed in renal transplant children, 19 boys and 13 girls, aged 2.5-18 yr, who had been on a cyclosporin-A (CsA)-based immunosuppressive regimen for at least 12 months. Data collected included number of posttransplant months, total CsA dose administered during the first 6 posttransplant months, oral dose and blood trough level of CsA on the day of examination, plaque accumulation (VPI%), gingival inflammation (GBI%), loss of attachment, and gingival overgrowth. Thirteen percent of the children exhibited gingival overgrowth characterized by one or more units with increased sulcus probing depth (> or = 4 mm), i.e. pseudopockets. The total amount of CsA administered during the first 6 posttransplant months was significantly higher in the children with gingival overgrowth than in those without. The study indicates that the development of CsA-induced gingival overgrowth is positively related to the total dose of the drug administered to the children during the first 6 posttransplant months.
对19名男孩和13名女孩、年龄在2.5至18岁之间的肾移植儿童的牙龈增生情况进行了评估，这些儿童接受基于环孢素A（CsA）的免疫抑制方案治疗至少12个月。收集的数据包括移植后月数、移植后前6个月给予的CsA总剂量、检查当天CsA的口服剂量和血药谷浓度、菌斑积聚（VPI%）、牙龈炎症（GBI%）、附着丧失和牙龈增生。13%的儿童出现牙龈增生，其特征为一个或多个单位的龈沟探诊深度增加（≥4mm），即假性牙周袋。移植后前6个月给予CsA总量，牙龈增生儿童显著高于未出现增生的儿童。该研究表明，CsA诱导的牙龈增生的发生与移植后前6个月给予儿童的药物总剂量呈正相关。
