Lin T, Grimes P A, Stone R A
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, School of Medicine, Philadelphia 19104-6075.
Vision Res. 1993 Sep;33(14):1881-5. doi: 10.1016/0042-6989(93)90015-o.
Expansion of the retinal pigment epithelium was studied in neonatal chicks after one or two weeks of unilateral form vision deprivation to investigate altered ocular growth mechanisms in this experimental model of myopia. The area of individual retinal pigment epithelial (RPE) cells, measured in tangential sections, was greater in myopic eyes than in contralateral control eyes at both times. The mean RPE cell area in myopic eyes increased to the same extent as the area of the retinal pigment epithelium as a whole. In control eyes between one and two weeks, RPE cell expansion occurred predominantly in the periphery; in myopic eyes, it occurred more generally across the epithelium but was less pronounced in the temporal region. Given the absence of detectable mitotic figures in control and myopic eyes, expansion of the epithelial layer is attributable to passive stretch or growth of existing cells. Whether scleral growth or stretch occurs selectively beneath the areas of more pronounced RPE cell expansion is unknown.
在新生小鸡单侧剥夺形觉一或两周后，对视网膜色素上皮的扩张进行了研究，以探究该近视实验模型中眼生长机制的改变。在两个时间点，通过切线切片测量的单个视网膜色素上皮（RPE）细胞的面积，近视眼中均大于对侧对照眼。近视眼中RPE细胞的平均面积增加程度与整个视网膜色素上皮的面积相同。在对照眼中，一到两周期间，RPE细胞扩张主要发生在外周；在近视眼中，它更普遍地发生在上皮细胞层，但在颞侧区域不太明显。鉴于在对照眼和近视眼中均未检测到有丝分裂象，上皮层的扩张归因于现有细胞的被动伸展或生长。尚不清楚巩膜生长或伸展是否在RPE细胞扩张更明显的区域下方选择性发生。
