Crafoord S, Stenkula S
Department of Opthalmology, Orebro Medical Center Hospital, Sweden.
Acta Ophthalmol (Copenh). 1993 Aug;71(4):560-1. doi: 10.1111/j.1755-3768.1993.tb04637.x.
Healon, a viscoelastic preparation of Sodium hyaluronate, has been reported effective in posterior segment surgery for dissection of epiretinal membranes, i.e. proliferative diabetic retinopathy and macular pucker. A more viscous substance might be more effective for this kind of surgery. Therefore, a new Sodium hyaluronate preparation Healon GV with a ten times greater viscosity at rest than Healon, was tested in an open clinical study. Twenty-four patients of both sexes and not younger than 18 years were enrolled. The follow-up time was three months. The main indications for using Healon GV were: to separate membranes from the retina, to stop bleeding and to reposition a detached retina. 0.2-0.5 ml of Healon GV was injected through a 27 gauge bent cannula and at close of surgery irrigated out of the eye. Postoperatively the patients were monitored concerning intraocular pressure, vitreous clarity, anterior chamber flare and visual acuity. Healon GV was found to make the surgical procedure simpler and safer. No inflammatory reaction and no increase of IOP was observed.
透明质酸钠的粘弹性制剂Healon已被报道在视网膜后段手术中对视网膜前膜(即增殖性糖尿病视网膜病变和黄斑皱襞)的剥离有效。对于此类手术,粘性更高的物质可能更有效。因此,在一项开放性临床研究中对一种新型透明质酸钠制剂Healon GV进行了测试,其静态粘度比Healon高10倍。纳入了24名年龄不小于18岁的男女患者。随访时间为三个月。使用Healon GV的主要适应症为:将膜与视网膜分离、止血以及使脱离的视网膜复位。通过27号弯针注入0.2 - 0.5 ml的Healon GV,手术结束时从眼内冲洗出来。术后对患者的眼压、玻璃体清晰度、前房闪辉和视力进行监测。发现Healon GV使手术过程更简单、更安全。未观察到炎症反应和眼压升高。