头孢唑林-庆大霉素对肠球菌的协同作用。
Synergism of cefazolin-gentamicin against enterococci.
作者信息
Bourque M, Quintiliani R, Tilton R C
出版信息
Antimicrob Agents Chemother. 1976 Jul;10(1):157-63. doi: 10.1128/AAC.10.1.157.
Abstract
A miniaturized technique for detecting antibiotic synergy by using microliter volumes was perfected. With this microtiter serial dilution method, the effect of the previously untried combination of cefazolin and gentamicin on 10 strains of enterococci was evaluated. At clinically achievable concentrations, the combination of cefazolin and gentamicin was found to be synergistic against all 10 strains when the data were plotted in the form of an isobologram. These results were compared with the conventional method of detecting synergy in vitro, namely, the determination of the rate of killing of the microorganisms with the antibiotics, singly and in combination. Similar results were also observed. These findings indicate that the microtiter serial dilution technique is a useful method for the routine determination of drug synergy. Moreover, in a patient with penicillin hypersensitivity and enterococcal infection, the combination of cefazolin and gentamicin should be considered for possible therapy.
摘要
一种通过使用微升体积来检测抗生素协同作用的小型化技术得以完善。采用这种微量滴定系列稀释法，评估了头孢唑林和庆大霉素这一此前未尝试过的组合对10株肠球菌的作用。当以等效线图的形式绘制数据时，发现在临床可达到的浓度下，头孢唑林和庆大霉素的组合对所有10株菌株均具有协同作用。将这些结果与体外检测协同作用的传统方法（即分别和联合测定抗生素对微生物的杀灭率）进行了比较。也观察到了类似的结果。这些发现表明，微量滴定系列稀释技术是常规测定药物协同作用的一种有用方法。此外，对于青霉素过敏且患有肠球菌感染的患者，应考虑使用头孢唑林和庆大霉素的组合进行可能的治疗。
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