Gombert M E, Berkowitz L B, Cummings M C
Antimicrob Agents Chemother. 1983 Feb;23(2):245-7. doi: 10.1128/AAC.23.2.245.
The in vitro activities of N-formimidoyl thienamycin alone and in combination with amikacin and gentamicin were tested against 10 strains of Streptococcus faecalis. Synergy was demonstrated in 35% of the combinations tested by the microtiter checkerboard technique; 50% were found to be synergistic with time killing curves.
单独使用N-甲酰亚胺硫霉素以及将其与丁胺卡那霉素和庆大霉素联合使用时,对10株粪链球菌进行了体外活性测试。通过微量滴定棋盘技术测试的组合中,35%表现出协同作用;通过时间杀菌曲线发现50%具有协同作用。