源自外科重症监护病房的多重耐药奇异变形杆菌暴发：体外药敏模式
Outbreak of multiply drug-resistant Proteus mirabilis originating in a surgical intensive care unit: in vitro susceptibility pattern.
作者信息
Yoshikawa T T, Shibata S A, Chow A W, Guze L B
出版信息
Antimicrob Agents Chemother. 1978 Feb;13(2):177-9. doi: 10.1128/AAC.13.2.177.
Abstract
A multiply drug-resistant strain of Proteus mirabilis was isolated from 14 patients on a surgical service. Antimicrobial susceptibility studies demonstrated that the organism was highly resistant to numerous antibiotics, including gentamicin, tobramycin, and sisomicin. The organism was susceptible in vitro to amikacin but had low-level resistance to netilmicin. In vitro susceptibility studies with combinations of cephalothin with netilmicin and trimethoprim with sulfamethoxazole showed these drugs to be synergistic. Other drug combinations failed to act synergistically.
摘要
从14名外科患者中分离出一株多重耐药奇异变形杆菌。药敏试验表明，该菌对多种抗生素高度耐药，包括庆大霉素、妥布霉素和西索米星。该菌体外对阿米卡星敏感，但对奈替米星有低水平耐药。头孢噻吩与奈替米星以及甲氧苄啶与磺胺甲恶唑联合用药的体外药敏试验表明这些药物具有协同作用。其他药物组合未表现出协同作用。
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Colistin, sulphamethoxazole, and trimethoprim in synergy against Gram-negative bacteria.黏菌素、磺胺甲恶唑和甲氧苄啶协同对抗革兰氏阴性菌。
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