Wilkinson D, Anderson M, Gauntlett I S
Department of Anaesthesia, Taunton & Somerset NHS Trust, Musgrove Park Hospital, United Kingdom.
Anesth Analg. 1993 Dec;77(6):1139-42. doi: 10.1213/00000539-199312000-00010.
The effect of applying nitroglycerin or placebo ointment to the back of the hand before venipuncture and injection of propofol was investigated in 60 ASA physical status I unpremedicated women. Eighteen patients (67%) pretreated with nitroglycerin experienced no pain compared with 10 (33%) in the placebo group. Eleven in the placebo group experienced moderate or severe pain during injection compared with only one in the active group. The time of onset of pain in more than half the subjects occurred 10 s or longer after commencement of injection, and, in more than half the patients, the site at which pain was felt was above the injection site (with three subjects experiencing it in the shoulder). No patient had a headache or experienced postural hypotension. We conclude that nitroglycerin ointment applied to the back of the hand before injection reduces the incidence of painful injection with propofol.
在60例未接受术前用药的ASA身体状况I级女性患者中，研究了在静脉穿刺和注射丙泊酚前在手背涂抹硝酸甘油或安慰剂软膏的效果。18例（67%）接受硝酸甘油预处理的患者未感到疼痛，而安慰剂组为10例（33%）。安慰剂组有11例患者在注射过程中经历中度或重度疼痛，而活性组仅有1例。超过半数受试者疼痛发作时间在注射开始后10秒或更长时间，并且超过半数患者感到疼痛的部位在注射部位上方（3名受试者在肩部感到疼痛）。没有患者出现头痛或体位性低血压。我们得出结论，注射前在手背涂抹硝酸甘油软膏可降低丙泊酚注射疼痛的发生率。
