Singh Dhananjay Kumar, Jindal Parul, Singh Gaurav
Department of Anaesthesiology, Pain Management & ICU, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun, India.
Saudi J Anaesth. 2011 Jan;5(1):50-4. doi: 10.4103/1658-354X.76511.
Propofol has the disadvantage of causing pain or discomfort on injection. The aim of the study was to assess the efficacy of pretreatment with various drugs to alleviate the propofol injection pain.
One hundred American Society of Anesthesiology (ASA) I and II adults, scheduled for various elective surgical procedures under general anesthesia (GA), were included in the study. They were randomly divided into four groups having 25 patients in each group. Group A received pretreatment with intravenous (i.v.) magnesium sulfate, group B received i.v. granisetron, group C received i.v. nitroglycerine and group D was the control group. One-fourth of the total calculated induction dose of propofol was administered over a period of 5 seconds. The patients were asked about the pain on injection. The intensity of pain was assessed using verbal response. A score of 0-3 which corresponds to no, mild, moderate and severe pain was recorded.
All the three drugs reduced the incidence and intensity of pain on propofol injection but the order of efficacy in attenuation of pain on the propofol injection was granisetron > nitroglycerine > magnesium sulfate > control.
Granisetron was the most effective followed by nitroglycerine and magnesium sulfate in attenuating pain on propofol intravenous injection.
丙泊酚具有注射时引起疼痛或不适的缺点。本研究的目的是评估用各种药物预处理以减轻丙泊酚注射痛的疗效。
纳入100例美国麻醉医师协会（ASA）分级为I级和II级、计划在全身麻醉（GA）下进行各种择期手术的成年患者。他们被随机分为四组，每组25例患者。A组接受静脉注射硫酸镁预处理，B组接受静脉注射格拉司琼，C组接受静脉注射硝酸甘油，D组为对照组。将丙泊酚总诱导剂量的四分之一在5秒内注射完毕。询问患者注射时的疼痛情况。使用言语反应评估疼痛强度。记录0至3分，分别对应无疼痛、轻度疼痛、中度疼痛和重度疼痛。
所有三种药物均降低了丙泊酚注射时的疼痛发生率和强度，但在减轻丙泊酚注射痛方面的疗效顺序为格拉司琼>硝酸甘油>硫酸镁>对照组。
在减轻丙泊酚静脉注射痛方面，格拉司琼最有效，其次是硝酸甘油和硫酸镁。
