Rankinen T, Rauramaa R, Väisänen S, Penttilä I, Saarikoski S, Tuomilehto J, Nissinen A
Kuopio Research Institute of Exercise Medicine, Finland.
Atherosclerosis. 1993 Sep;102(2):181-6. doi: 10.1016/0021-9150(93)90160-v.
The relationship between habitual physical activity and plasma level of fibrinogen was investigated in a cohort of 180 postmenopausal women, aged 60-69 years. Plasma fibrinogen was determined from prediluted plasma by adding an appropriate amount of thrombin to the sample. The time until fibrin formation occurred was measured. Physical activity during the month and year preceding the examination was assessed using self-administered questionnaires. There was a statistically significant inverse relationship between physical activity and fibrinogen (beta = -0.20; P = 0.005). For further analyses of the association between physical activity and fibrinogen the subjects were classified into three categories according to their weekly physical activity frequency: 0 to 1, 2 to 3, and 4 or more during the preceding month. The mean (S.D. [95% CI]) levels of fibrinogen from lowest to highest categories were: 3.49 (1.10 [2.99, 3.99]), 3.31 (1.52 [2.82, 3.81]), and 3.20 (2.26 [2.73, 3.67]) g/l, respectively, when age, body mass index (BMI), smoking, alcohol intake, LDL-cholesterol and estrogen use were allowed for (P = 0.021). BMI was directly associated with fibrinogen (beta = 0.30; P < 0.001), especially in the physically least active women. Smoking was directly (beta = 0.19; P = 0.006) and estrogen use inversely (beta = -0.15; P = 0.037) related to plasma fibrinogen level. The present data suggest that in postmenopausal women a low level of physical activity is associated with a high level of plasma fibrinogen.
在一个由180名年龄在60至69岁之间的绝经后女性组成的队列中，研究了习惯性身体活动与血浆纤维蛋白原水平之间的关系。通过向预稀释血浆中加入适量凝血酶来测定血浆纤维蛋白原。测量纤维蛋白形成所需的时间。使用自行填写的问卷评估检查前一个月和一年期间的身体活动情况。身体活动与纤维蛋白原之间存在统计学上显著的负相关关系（β = -0.20；P = 0.005）。为了进一步分析身体活动与纤维蛋白原之间的关联，根据受试者前一个月的每周身体活动频率将其分为三类：0至1次、2至3次以及4次或更多次。在考虑年龄、体重指数（BMI）、吸烟、饮酒、低密度脂蛋白胆固醇和雌激素使用情况后，从最低到最高类别的纤维蛋白原平均（标准差[95%置信区间]）水平分别为：3.49（1.10[2.99, 3.99]）、3.31（1.52[2.82, 3.81]）和3.20（2.26[2.73, 3.67]）g/l（P = 0.021）。BMI与纤维蛋白原呈正相关（β = 0.30；P < 0.001），尤其是在身体活动最少的女性中。吸烟与血浆纤维蛋白原水平呈正相关（β = 0.19；P = 0.006），而雌激素使用则呈负相关（β = -0.15；P = 0.037）。目前的数据表明，在绝经后女性中，低水平的身体活动与高水平的血浆纤维蛋白原相关。
