Ghosh K, Sivakumaran M, Wood J K
Department of Hameatology, Leicester Royal Infirmary.
Br J Haematol. 1993 Sep;85(1):205-6. doi: 10.1111/j.1365-2141.1993.tb08673.x.
Co-expression of T cell antigens in B-CLL has been well recognized. The commonest T cell antigen known to be expressed in B-CLL is CD5, and recent reports suggest that CD5 expression is associated with good prognosis. Expression of CD8 antigen, however, is much less common with uncertain prognostic significance. We report a case of B-CLL with aberrant CD8 expression, who had unusual disease progression with a fatal outcome.
B淋巴细胞慢性淋巴细胞白血病（B-CLL）中T细胞抗原的共表达已得到充分认识。已知在B-CLL中表达的最常见T细胞抗原是CD5，最近的报告表明CD5表达与良好预后相关。然而，CD8抗原的表达则少见得多，其预后意义尚不确定。我们报告1例伴有异常CD8表达的B-CLL病例，该患者病情进展异常，最终死亡。
