Department of Pathology, King George's Medical University, Uttar Pradesh, India.
Department of Clinical Hematology, King George's Medical University, Uttar Pradesh, India.
Cytometry B Clin Cytom. 2018 Jul;94(4):679-682. doi: 10.1002/cyto.b.21535. Epub 2017 Jun 11.
Immuno-phenotyping forms an integral part of laboratory work up of Chronic lymphocytic leukemia (CLL). Aberrant antigen expressions are a known phenomenon in leukemic blasts, however cross lineage antigen expression is rarely seen in mature B cell leukemia, the reported percentages varying from 1% to 3% in Europe and North America.
We report a case of Rai stage 1 CLL showing aberrant expression of CD8 on flow cytometry. The patient had stable disease at a follow up of 9 months with no requirement of initiation of treatment.
CD8 expression in CLL is rare and approximately 120 cases have been reported from Western population. To the best of our knowledge, this is the first case to be reported from India. The prognostic significance has been variably reported from favorable to poor. At present, our case reflects the phenotypic heterogeneity of leukemia. Long term follow up and evaluation of more cases is required to predict the prognostic role in our patient population. © 2017 International Clinical Cytometry Society.
免疫表型分析是慢性淋巴细胞白血病（CLL）实验室检测的一个组成部分。异常抗原表达是白血病细胞中的已知现象，然而在成熟 B 细胞白血病中很少见到跨谱系抗原表达，在欧洲和北美的报道百分比为 1%至 3%。
我们报告了一例 Rai 分期 1 期 CLL 患者，其流式细胞术显示 CD8 异常表达。该患者在 9 个月的随访中疾病稳定，无需开始治疗。
CLL 中 CD8 的表达很少见，大约有 120 例已在西方人群中报道。据我们所知，这是首例在印度报道的病例。其预后意义的报道结果从有利到不利各不相同。目前，我们的病例反映了白血病的表型异质性。需要进行长期随访和更多病例的评估，以预测在我们的患者人群中的预后作用。©2017 年国际临床细胞遗传学学会。
