De Buyzere M, Clement D L, De Sutter J, Duprez D
Department of Cardiology, University Hospital, Gent, Belgium.
Eur J Med. 1993 May;2(5):269-74.
The relationship between regional circulation (blood flow or calculated resistance) and systemic blood pressure (BP) is only poorly documented in the range of intermediate to low BP.
In 75 subjects covering the BP range from low, over intermediate, to high BP, venous occlusion plethysmographic recordings were performed at the calf and finger vessels. Correlations were calculated between regional blood flow or vascular resistance and BP defined from office and from 24 h ambulatory BP registrations, at rest and during reactive hyperaemia.
At any BP level, finger blood flow at rest and during reactive hyperemia was higher than calf blood flow, and resistance was lower. The interval of 90-100 mmHg office diastolic BP was characterized by significantly (p < 0.001) higher resting finger blood flow; the increase in resting muscle blood flow was less pronounced. At rest and during reactive hyperaemia there was a stepwise increase in calf regional vascular resistance in parallel with increasing BP. For the finger circulation, increased vascular resistance was only observed for the higher BP values. Correlations between calf and finger vascular resistances and BP were positive and highly significant over the whole BP range, both for office (0.650 < r < 0.776) and for ambulatory BP (0.531 < r < 0.781). These correlations remained significant after adjustment for the age dependency. Increases in calf and finger blood flow induced by arterial occlusion were highest for the lowest BP quintiles.
Our data further indicated that the capacity to dilate decreased progressively with increasing BP level (from asymptomatic low to high BP) for both calf and finger circulation.
在中低血压范围内，关于局部循环（血流量或计算得出的阻力）与全身血压（BP）之间的关系，相关文献记载甚少。
对75名涵盖从低血压、经中血压到高血压范围的受试者，在小腿和手指血管处进行静脉阻塞体积描记记录。计算局部血流量或血管阻力与通过诊室血压及24小时动态血压记录所定义的血压之间的相关性，记录状态为静息时和反应性充血期间。
在任何血压水平下，静息时和反应性充血期间手指血流量均高于小腿血流量，且阻力更低。诊室舒张压90 - 100 mmHg区间的特征是静息时手指血流量显著更高（p < 0.001）；静息时肌肉血流量的增加则不太明显。静息时和反应性充血期间，小腿局部血管阻力随着血压升高呈逐步增加。对于手指循环，仅在较高血压值时观察到血管阻力增加。小腿和手指血管阻力与血压之间的相关性在整个血压范围内均为正且高度显著，诊室血压（0.650 < r < 0.776）和动态血压（0.531 < r < 0.781）均如此。在调整年龄依赖性后，这些相关性仍然显著。动脉阻塞引起的小腿和手指血流量增加在最低血压五分位数组中最高。
我们的数据进一步表明，对于小腿和手指循环，随着血压水平升高（从无症状低血压到高血压），扩张能力逐渐下降。
