Gray K A, Mitchell G M, Gurusinghe C J, Romeo R, Crowe D M, Olivier T V, Morrison W A
Microsurgery Research Centre, St Vincent's Hospital, Melbourne, Australia.
Br J Plast Surg. 1993 Oct;46(7):570-5. doi: 10.1016/0007-1226(93)90107-m.
The effects of hypothermic ischaemia on blood vessels are unknown. This study aimed to determine the 3 week patency rate and the pathology of 9 experimental groups of hypothermically stored ischaemic arteries and one control group in a rabbit femoral artery model. Ischaemia times were 0 h, 24 h, 1, 2, 4, 6, 8 and 10 weeks (Groups 1-8). Patency was over 80% in all groups after 3 weeks reinsertion. Following reinsertion control grafts maintained normal arterial structure, but cellular degeneration had occurred in all ischaemic grafts and appeared complete after 4 weeks ischaemia. The graft connective tissue framework frequently remained intact. Repair was evident in central graft regions after 2 weeks ischaemia and 3 weeks reinsertion, but occurred only adjacent to the anastomosis in 4-10 week ischaemic arteries. Four week ischaemic arteries (Groups 9 and 10) reinserted for 6 and 12 weeks respectively exhibited near complete repair but patency dropped to 60% in the 12 week group.
低温缺血对血管的影响尚不清楚。本研究旨在确定兔股动脉模型中9个低温保存缺血动脉实验组和1个对照组的3周通畅率及病理学情况。缺血时间分别为0小时、24小时、1周、2周、4周、6周、8周和10周（第1 - 8组）。重新植入3周后，所有组的通畅率均超过80%。重新植入后，对照移植物保持正常动脉结构，但所有缺血移植物均发生细胞变性，且缺血4周后细胞变性似乎完全。移植物结缔组织框架通常保持完整。缺血2周和重新植入3周后，移植物中央区域可见修复，但在缺血4 - 10周的动脉中，修复仅发生在吻合口附近。分别重新植入6周和12周的4周缺血动脉（第9组和第10组）显示近乎完全修复，但12周组的通畅率降至60%。
