Patel P, Goldberg D, Moss S
Hester Adrian Research Centre, University of Manchester.
Br J Psychiatry. 1993 Oct;163:481-91. doi: 10.1192/bjp.163.4.481.
We present a prevalence study of psychiatric morbidity in people over 50 years of age with learning disability (LD), using a new semistructured clinical interview specifically for use with people who have LD (the 'PAS-ADD'). Assessment involved parallel interviewing of subject and informant, these two sets of information being combined to reach a final diagnosis using ICD-9 and DSM-III-R criteria. Detection of dementia involved interviews with informants, plus investigation of loss of cognitive function over a three-year period. The experimental sample was a mixed community and institutional group (n = 105), including, as far as possible, all people in a single administrative district (Oldham) matching the age and ability criteria. Prevalence of psychiatric disorder excluding dementia was 11.4% (n = 12), most of which were depression and anxiety. Seventy-five per cent of these cases were unknown to mental health services. However, immediate care staff were usually aware of the symptoms, although often unaware of their clinical significance. Prevalence of dementia was also 11.4% (n = 12), with a combined case prevalence of 21.0% (n = 22). The PAS-ADD proved a flexible interview, effective in use with people of varying linguistic level and intellectual ability: 61.9% (n = 65) of the sample were able to be interviewed, fully adequate clinical interviews being obtained with a group of 38 people whose mean IQ was only 39. In the remaining 38.1% (n = 40), diagnosis relied exclusively on informant data. Overall, the combination of subject and informant data was essential for sensitive case detection.
我们采用一种专门为学习障碍(LD)患者设计的新型半结构化临床访谈(“PAS-ADD”),对50岁以上有学习障碍的人群进行了精神疾病患病率研究。评估包括对受试者和提供信息者进行平行访谈,将这两组信息结合起来,依据国际疾病分类第9版(ICD-9)和《精神疾病诊断与统计手册》第三版修订本(DSM-III-R)标准做出最终诊断。痴呆症的检测包括与提供信息者访谈,以及对三年期间认知功能丧失情况的调查。实验样本是一个社区和机构混合组(n = 105),尽可能纳入了单一行政区(奥尔德姆)内所有符合年龄和能力标准的人群。排除痴呆症后的精神疾病患病率为11.4%(n = 12),其中大部分是抑郁症和焦虑症。这些病例中有75%精神卫生服务机构并不知晓。然而,即时护理人员通常能察觉到症状,尽管往往未意识到其临床意义。痴呆症患病率也是11.4%(n = 12),合并患病率为21.0%(n = 22)。事实证明,PAS-ADD是一种灵活的访谈方式,对不同语言水平和智力能力的人都有效:61.9%(n = 65)的样本能够接受访谈,对一组平均智商仅为39的38人进行了充分的临床访谈。在其余38.1%(n = 40)的样本中,诊断完全依赖于提供信息者的数据。总体而言,受试者和提供信息者的数据结合对于敏感的病例检测至关重要。