关于RNA肿瘤病毒信息及其在B16小鼠黑色素瘤中传播的生化研究。

Biochemical studies on RNA tumor virus information and its transmission in B16 murine melanoma.

作者信息

Hehlmann R, Erfle V

出版信息

Int J Cancer. 1978 Nov 15;22(5):630-8. doi: 10.1002/ijc.2910220519.

DOI:10.1002/ijc.2910220519

Abstract

The mouse melanoma B16 contains particles encapsulating a high molecular weight RNA of 60--70S size associated with a reverse transcriptase. The particles possess a density of 1.14--1.18 g/cm3. The RNA shares sequences with the 70S RNAs of several mammalian C-type RNA tumor viruses. The nuclear DNA of the mouse melanoma B16 possesses particle-related sequences not present in the genome of normal C57BL mice.

摘要

小鼠黑色素瘤B16含有包裹着与逆转录酶相关的60 - 70S大小的高分子量RNA的颗粒。这些颗粒的密度为1.14 - 1.18 g/cm³。该RNA与几种哺乳动物C型RNA肿瘤病毒的70S RNA具有共同序列。小鼠黑色素瘤B16的核DNA拥有正常C57BL小鼠基因组中不存在的与颗粒相关的序列。