人类皮肤癌中的类肿瘤病毒颗粒。
Oncornavirus-like particles in human skin cancers.
作者信息
Balda B R, Hehlmann R, Cho J R, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3697-700. doi: 10.1073/pnas.72.9.3697.
Abstract
A high-molecular-weight RNA encapsulated with an RNA-instructed DNA polymerase in particles possessing the density characteristic of the RNA tumor viruses has been detected in 13 out of 14 human malignant melanomas. The [3H]DNA synthesized by these particles in an endogenous reaction hybridizes to RNA extracted from the human melanoma particulate structures, but not to RNA from normal skin. Similar particles containing RNA and enzyme have been found in basal cell and squamous cell carcinomas of the skin. The RNA of the melanoma particles is easily distinguishable by hybridization from the RNAs found in the particles of the basal and squamous cell carcinomas.
摘要
在14例人类恶性黑色素瘤中，有13例检测到一种高分子量RNA，它与一种RNA指导的DNA聚合酶一起包裹在具有RNA肿瘤病毒密度特征的颗粒中。这些颗粒在体内反应中合成的[3H]DNA与从人类黑色素瘤颗粒结构中提取的RNA杂交，但不与正常皮肤的RNA杂交。在皮肤基底细胞癌和鳞状细胞癌中也发现了含有RNA和酶的类似颗粒。黑色素瘤颗粒的RNA通过杂交很容易与基底细胞癌和鳞状细胞癌颗粒中的RNA区分开来。
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