Messiha F S
University of North Dakota School of Medicine, Grand Forks.
J Toxicol Clin Toxicol. 1993;31(4):603-30. doi: 10.3109/15563659309025765.
This overview summarizes the major and minor side effects and drug interactions of fluoxetine. The adverse reactions include the "serotonin syndrome", cardiovascular complications, extrapyramidal side effects such as akathisia, dyskinesias, and parkinsonian-like syndromes and an apparently increased risk of suicidality. Fluoxetine-induced mania and hypomania, seizures and sexual disorders are evaluated along with minor symptoms of allergic reactions, stuttering, hematological changes, psoriasis, and inappropriate secretion of the antidiuretic hormone. The major fluoxetine-drug interactions involve the amino acids L-dopa and L-tryptophan, anorexiants, anticonvulsants, antidepressants, anxiolytics, calcium channel blockers, cyproheptadine, lithium salts, and drugs of abuse. The underlying mechanism and the paradoxical effects of fluoxetine are addressed.
本综述总结了氟西汀的主要和次要副作用以及药物相互作用。不良反应包括“5-羟色胺综合征”、心血管并发症、锥体外系副作用，如静坐不能、运动障碍和帕金森样综合征，以及明显增加的自杀风险。还对氟西汀诱发的躁狂和轻躁狂、癫痫发作和性功能障碍，以及过敏反应、口吃、血液学变化、银屑病和抗利尿激素分泌不当等轻微症状进行了评估。主要的氟西汀药物相互作用涉及氨基酸左旋多巴和左旋色氨酸、食欲抑制剂、抗惊厥药、抗抑郁药、抗焦虑药、钙通道阻滞剂、赛庚啶、锂盐和滥用药物。文中还探讨了氟西汀的潜在机制和矛盾效应。
