Espinoza E, Cordero M, Muro A, Lorente F, Simón F
Laboratory of Parasitology, Faculty of Pharmacy, University of Salamanca, Spain.
Trop Med Parasitol. 1993 Sep;44(3):172-6.
The seroprevalence of seasonal variation of human anti-Dirofilaria immitis IgE levels were studied in an area where specific IgM and IgG had been previously investigated. An antibody capture ELISA assay was used to detect specific IgE. The IgE seroprevalence observed in the whole population was 12.6%. No specific IgE was detected in atopic individuals or in sera from people suffering other helminthiases. The distribution of the IgE anti-D. immitis seroprevalence by age groups did not show differences. Females had significantly higher levels than males. This isotype of immunoglobulin peaks in July, decreasing sharply in October, and persisting at a level similar to that of a non exposed population during the rest of the year. No specific IgE were detected in subjects with pulmonary alterations related to the parasite, suggesting a possible relationship between the clinico-radiological status and the type of immunoglobulin synthesized in subjects infected by D. immitis.
在先前已对特异性IgM和IgG进行过调查的一个地区，研究了人类抗犬恶丝虫IgE水平季节性变化的血清阳性率。采用抗体捕获ELISA检测法来检测特异性IgE。在整个人群中观察到的IgE血清阳性率为12.6%。在特应性个体或患有其他蠕虫病的人的血清中未检测到特异性IgE。按年龄组划分的抗犬恶丝虫IgE血清阳性率分布未显示出差异。女性的水平显著高于男性。这种免疫球蛋白同型在7月达到峰值，10月急剧下降，在一年中的其余时间里维持在与未接触人群相似的水平。在与该寄生虫相关的肺部病变患者中未检测到特异性IgE，这表明在感染犬恶丝虫的患者中，临床放射学状态与合成的免疫球蛋白类型之间可能存在关联。
