Barakat R, Farghaly A, el-Sawy M F, Soliman N K, Duncan J, Zaki A, Miller F D
Department of Parasitology, High Institute of Public Health, Alexandria, Egypt.
Trop Med Parasitol. 1993 Sep;44(3):181-6.
Ambrosia maritima (Damsissa), a proven molluscicide, was investigated in a seven year epidemiological trial in four villages in the northern Egyptian Nile Delta. Schistosoma mansoni prevalence and other measures of infection were initially high in the four villages before the trial began. Two villages were used to test the impact of A. maritima application both on snail populations and on infection in the village population. Two villages were held as controls and not treated with A. maritima. The entire population of all four villages was included in the study. Prevalence and other measures of infection fell dramatically following treatment with praziquantel 40 mg kg-1 body weight. On annual follow ups, the prevalence of infection and geometric mean egg counts began to increase back to original levels in both test and control villages; age adjusted incidence rates were lower in one test village, but higher in the other when compared to the control villages. Snail populations were destroyed in the treated canals and drains located near the test villages. The lack of a clear epidemiologic impact is discussed.
海沙蓬（Damsissa）是一种经证实有效的杀螺剂，在埃及尼罗河三角洲北部的四个村庄进行了为期七年的流行病学试验。在试验开始前，这四个村庄的曼氏血吸虫感染率及其他感染指标最初都很高。其中两个村庄用于测试施用海沙蓬对螺类种群以及村庄人群感染情况的影响。另外两个村庄作为对照，未施用海沙蓬。所有四个村庄的全部人口都纳入了研究。用40毫克/千克体重的吡喹酮治疗后，感染率及其他感染指标大幅下降。在年度随访中，试验村庄和对照村庄的感染率及虫卵几何平均计数开始回升至原来的水平；与对照村庄相比，一个试验村庄的年龄调整发病率较低，而另一个试验村庄的则较高。试验村庄附近经处理的运河和排水沟中的螺类种群被消灭。文中讨论了缺乏明确流行病学影响的情况。
