Heidmann J M, Arnbjerg D, Poulsen S, Kirkegaard E, Laurbjerg L
Aarhus Universitet, Odontologisk Institut.
Ugeskr Laeger. 1993 Sep 20;155(38):2995-8.
In a municipality near Copenhagen, Denmark, where fortnightly fluoride rinses with 0.2% neutral sodium fluoride had been performed for more than a decade, 1306 children from kindergarten through sixth grade were stratified by school and grade and randomly distributed into two groups. One group continued with the fluoride rinses, the other group had the fluoride solution replaced with distilled water. Both solutions were slightly flavored. One thousand and eighty-three children completed the three-year trial. Caries was recorded clinically by the dentists in the municipal dental service using criteria common for the Child Dental Health Services, and on bitewing radiographs by one of the authors applying criteria developed by Gröndahl et al. Permanent molars and premolars were included in the study. Clinically, caries increment in the two groups was the same, with 94% of caries lesions and fillings situated in pits and fissures. According to the radiographs, caries progression in the water group was higher than in the fluoride group. This difference was statistically significant for the surfaces erupting during the study (p < 0.05).
在丹麦哥本哈根附近的一个自治市,十多年来一直每两周用0.2%的中性氟化钠进行一次氟化物漱口。1306名从幼儿园到六年级的儿童按学校和年级分层,并随机分为两组。一组继续进行氟化物漱口,另一组用蒸馏水代替氟化物溶液。两种溶液都有轻微的味道。1083名儿童完成了这项为期三年的试验。市牙科服务部门的牙医按照儿童牙科保健服务通用标准对龋齿进行临床记录,其中一位作者按照格伦达尔等人制定的标准在咬合翼片X光片上记录龋齿情况。研究纳入了恒磨牙和前磨牙。临床上,两组的龋齿增量相同,94%的龋损和补牙位于窝沟处。根据X光片,用水组的龋齿进展高于用氟化物组。对于研究期间萌出的表面,这种差异具有统计学意义(p < 0.05)。