Glabiński A, Tawsek N S, Bartosz G
Department of Neurology, Medical School, Lódź, Poland.
Acta Neurol Scand. 1993 Sep;88(3):174-7. doi: 10.1111/j.1600-0404.1993.tb04212.x.
Increased generation of superoxide radical (O2-) in the blood stimulated with phorbol myristate acetate (PMA) has been found in multiple sclerosis (MS) patients. All the subjects studied were non-smokers and received the same hospital diet. In the MS group treated with prednisone superoxide radical generation was lower than in untreated patients, but was still above the level of O2- generation in controls. Plasma lipid peroxidation products, measured as thiobarbituric-reactive substances, were slightly elevated in both prednisone treated and non-treated MS patients in comparison with controls. Erythrocyte superoxide dismutase activity (SOD) was at the same level in MS and control groups. These results suggest that increased generation of reactive oxygen species may occur in MS patients during acute relapse. This phenomenon may be involved in the pathomechanism of demyelinating disorders.
在多发性硬化症（MS）患者中发现，用佛波酯肉豆蔻酸酯（PMA）刺激血液时，超氧阴离子自由基（O2-）的生成增加。所有研究对象均为非吸烟者，且接受相同的医院饮食。在接受泼尼松治疗的MS组中，超氧阴离子自由基的生成低于未治疗的患者，但仍高于对照组的O2-生成水平。与对照组相比，用硫代巴比妥酸反应性物质测定的血浆脂质过氧化产物在接受泼尼松治疗和未治疗的MS患者中均略有升高。MS组和对照组的红细胞超氧化物歧化酶活性（SOD）处于同一水平。这些结果表明，MS患者在急性复发期间可能会出现活性氧生成增加。这种现象可能参与了脱髓鞘疾病的发病机制。
