全身冷冻疗法对多发性硬化症女性氧化-抗氧化失衡的影响。
Effect of Whole-Body Cryotherapy on Oxidant-Antioxidant Imbalance in Women with Multiple Sclerosis.
作者信息
Ptaszek Bartłomiej, Podsiadło Szymon, Adamiak Justyna, Marchewka Jakub, Tota Łukasz, Teległów Aneta
机构信息
Institute of Applied Sciences, University of Physical Education in Krakow, 31-571 Krakow, Poland.
Institute of Clinical Rehabilitation, University of Physical Education in Krakow, 31-571 Krakow, Poland.
出版信息
J Clin Med. 2023 Sep 13;12(18):5958. doi: 10.3390/jcm12185958.
The aim of the study was to investigate whether 20 whole-body cryotherapy treatments have an effect on oxidative-antioxidant imbalances in women with multiple sclerosis. Fifty women aged 30-55 were examined: study group-15 women with multiple sclerosis, subjected to whole-body cryotherapy; first control group-20 women with multiple sclerosis who did not receive cryotherapy intervention; second control group-15 healthy women who participated in cryotherapy treatments. Blood from the examined women was collected twice (before and after the series of 20 cryotherapy sessions). An insignificant increase in the total antioxidant capacity (study group: = 0.706; second control group: = 0.602) was observed after the whole-body cryotherapy intervention. After the series of cryotherapy sessions, the total oxidative status/total oxidative capacity value was insignificantly decreased among the multiple sclerosis patients (decrease by 14.03%, = 0.495). In women with multiple sclerosis, no significant cryotherapy impact was demonstrated on changes in the oxidant-antioxidant imbalance or concentrations of nitric oxide, uric acid, or matrix metalloproteinase-9.
本研究的目的是调查20次全身冷冻疗法治疗对多发性硬化症女性氧化-抗氧化失衡是否有影响。对50名年龄在30至55岁的女性进行了检查：研究组——15名患有多发性硬化症的女性，接受全身冷冻疗法；第一对照组——20名未接受冷冻疗法干预的多发性硬化症女性；第二对照组——15名参与冷冻疗法治疗的健康女性。对受检女性的血液进行了两次采集（在20次冷冻疗法疗程之前和之后）。全身冷冻疗法干预后，观察到总抗氧化能力有不显著增加（研究组：= 0.706；第二对照组：= 0.602）。在一系列冷冻疗法疗程后，多发性硬化症患者中总氧化状态/总氧化能力值有不显著下降（下降14.03%，= 0.495）。在患有多发性硬化症的女性中，未证明冷冻疗法对氧化-抗氧化失衡的变化或一氧化氮、尿酸或基质金属蛋白酶-9的浓度有显著影响。
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