Lycke J, Svennerholm B, Svenningsson A, Horal P, Nordqvist-Brandt E, Andersen O
Dept of Neurology, University of Gothenburg, Sahlgren's Hospital, Sweden.
Acta Neurol Scand. 1993 Sep;88(3):199-203. doi: 10.1111/j.1600-0404.1993.tb04216.x.
We report a Swedish patient with progressive dementia possibly associated with human T cell-lymphotropic virus type I (HTLV-I) infection. The clinical investigation revealed no typical sings of other neurological disorders. The patient was probably infected in East-Asia 35 years before onset of the disease. High titers of specific HTLV-I antibodies were detectable with solid-phase peptide ELISA in serum (1:1.600) and cerebrospinal fluid (CSF) (1:20), and the CSF/serum anti-HTLV-I antibody ratio indicated intrathecal HTLV-I antibody synthesis. Western blot for HTLV-I and polymerase chain reaction with primers selected for the HTLV-I pol gene were positive in both peripheral blood and cerebrospinal fluid. HTLV-I antigen was also demonstrated after in vitro co-cultivation of mononuclear cells from peripheral blood. Thus, our findings indicate that HTLV-I infection also may be associated with dementia. In addition, this case report calls attention upon HTLV-I as a possible etiologic agent to neurological diseases in countries previously spared from the infection.
我们报告了一名瑞典患者，患有可能与I型人类嗜T细胞病毒（HTLV-I）感染相关的进行性痴呆。临床调查未发现其他神经系统疾病的典型体征。该患者可能在疾病发作前35年于东亚感染。通过固相肽ELISA在血清（1:1600）和脑脊液（CSF）（1:20）中可检测到高滴度的特异性HTLV-I抗体，并且脑脊液/血清抗HTLV-I抗体比值表明存在鞘内HTLV-I抗体合成。针对HTLV-I的蛋白质印迹法以及使用针对HTLV-I pol基因选择的引物进行的聚合酶链反应在外周血和脑脊液中均呈阳性。从外周血分离的单核细胞进行体外共培养后也证实了HTLV-I抗原的存在。因此，我们的研究结果表明HTLV-I感染也可能与痴呆有关。此外，本病例报告提醒人们注意HTLV-I作为以前未受该感染影响国家中神经系统疾病的一种可能病因。
