Cerveri I, Fanfulla F, Zoia M C, Manni R, Tartara A
Institute of Respiratory Diseases, University of Pavia, Italy.
Monaldi Arch Chest Dis. 1993 Aug;48(4):318-21.
This article reports the results of several studies on neuromuscular patients (9 Duchenne's muscular dystrophy, 10 myotonic muscular dystrophy, 8 mitochondrial myopathies, 6 spinal muscular atrophy). An evaluation of respiratory function during wakefulness, a sleep questionnaire and an overnight polysomnography were performed in all patients. Recurrent hypoxaemia of variable degree was observed during sleep. In most cases, night-time hypoxaemia appears not to be predictable during wakefulness. Nocturnal hypoxaemia occurs in relation to apnoeas or hypopnoeas, mainly of central type, especially when these breathing irregularities occur during rapid eye movement (REM) sleep. Moreover, polygraphic sleep-apnoea patterns, as defined by international criteria, seem to be an infrequent condition, except for those neuromuscular diseases, characterized by an involvement of the central nervous system.
本文报告了对神经肌肉疾病患者（9例杜氏肌营养不良症、10例强直性肌营养不良症、8例线粒体肌病、6例脊髓性肌萎缩症）的几项研究结果。对所有患者进行了清醒时呼吸功能评估、睡眠问卷调查和夜间多导睡眠图检查。在睡眠期间观察到不同程度的反复低氧血症。在大多数情况下，夜间低氧血症在清醒时似乎无法预测。夜间低氧血症与呼吸暂停或呼吸不足有关，主要是中枢性的，尤其是当这些呼吸不规则发生在快速眼动（REM）睡眠期间时。此外，除了那些以中枢神经系统受累为特征的神经肌肉疾病外，按照国际标准定义的多导睡眠呼吸暂停模式似乎并不常见。
