Manni R, Piccolo G, Sartori I, Castelnovo G, Raiola E, Lombardi M, Cerveri I, Fanfulla F, Tartara A
Istituto Neurologico C. Mondino, Università di Pavia, Italy.
Ital J Neurol Sci. 1995 Dec;16(9):589-94. doi: 10.1007/BF02230908.
The aim of this study was to assess breathing patterns during sleep in patients with generalized mild myasthenia gravis. Fourteen patients (13 F; 1M, age range 20-40 years) in a stable clinical and functional state underwent a sleep questionnaire, baseline respiratory function tests and standard nocturnal polysomnography. All of the patients had normal daytime blood-gas values, except one who showed mild hypoxemia. No patient complained of disturbed sleep; six patients reported snoring. In five patients nocturnal polysomnography showed the occurrence of short and infrequent central apneas mainly during REM sleep, together with a drop in HbSaO2 levels of more than 5% of the baseline wakefulness value. Our data indicate that, in patients with mild generalized MG in a stable functional state, breathing pattern instability during sleep is infrequent and, when it occurs, is mild and mainly related to REM sleep.
本研究的目的是评估轻度全身型重症肌无力患者睡眠期间的呼吸模式。14例处于临床和功能稳定状态的患者（13例女性；1例男性，年龄范围20 - 40岁）接受了睡眠问卷调查、基线呼吸功能测试和标准夜间多导睡眠图检查。除1例有轻度低氧血症外，所有患者白天血气值均正常。无患者主诉睡眠障碍；6例患者报告有打鼾。5例患者的夜间多导睡眠图显示主要在快速眼动睡眠期出现短暂且不频繁的中枢性呼吸暂停，同时血红蛋白氧饱和度（HbSaO2）水平较清醒基线值下降超过5%。我们的数据表明，处于功能稳定状态的轻度全身型重症肌无力患者睡眠期间呼吸模式不稳定的情况并不常见，一旦出现也较为轻微，且主要与快速眼动睡眠有关。
