Bollen E, Bax J, van Dijk J G, Koning M, Bos J E, Kramer C G, van der Velde E A
Department of Neurology, University Hospital, Leiden, The Netherlands.
Invest Ophthalmol Vis Sci. 1993 Dec;34(13):3700-4.
This study investigated the relationship between amplitude and peak velocity of saccadic eye movements (the so-called main sequence) and the intra-individual variability of the main sequence.
Saccadic amplitudes and peak velocities were measured twice in 58 healthy subjects with an infrared reflection technique.
Considerable intra-individual variability was found between the first and second recordings.
Intra-individual variability of saccadic peak velocity affects the interpretation of changes in repeated recordings of peak velocities, such as before and after medication is administered. Furthermore, considerable intra-individual variability decreases the probability that statistically significant differences between patients and control subjects can be detected, especially when groups are small. Calculating the intraclass correlation coefficient allows the number of subjects in comparative studies to be determined.
本研究调查了眼球扫视运动的幅度与峰值速度（即所谓的主序列）之间的关系以及主序列的个体内变异性。
采用红外反射技术对58名健康受试者的眼球扫视幅度和峰值速度进行了两次测量。
在第一次和第二次记录之间发现了相当大的个体内变异性。
眼球扫视峰值速度的个体内变异性会影响对峰值速度重复记录变化的解释，例如给药前后的变化。此外，相当大的个体内变异性降低了检测患者与对照受试者之间统计学显著差异的可能性，尤其是在样本量较小时。计算组内相关系数有助于确定比较研究中的受试者数量。
