Haney K L, McWhorter A G, Seale N S
Department of Pediatric Dentistry, Baylor College of Dentistry.
ASDC J Dent Child. 1993 Jul-Oct;60(4-5):288-94.
A retrospective study evaluated the success of orally administered meperidine (1.0 mg/lb) and promethazine (0.5 mg/lb) combined with N20:02, and determined predictors of success in a medically, physically and/or mentally compromised population. Behavior of 143 uncooperative patients (mean age 6.4 years) was evaluated during 282 sedations. A simplified Success Index rated outcome: 1-failure, 2-moderately successful; 3-highly successful. Variables were examined for effect on outcome of sedation: physical and/or neurologic component of medical diagnosis; previous hospital experience; medication category. Children taking medications with CNS actions were significantly less likely to have either moderately successful (p = .008) or highly successful appointments (p = .002). Children with a neurologic component to their medical diagnosis were significantly less likely to have a highly successful appointment (p = .001). Oral sedation was effective for this population (77 percent were successful) and certain characteristics of the patient's condition can predict success.
一项回顾性研究评估了口服哌替啶（1.0毫克/磅）和异丙嗪（0.5毫克/磅）联合N2O:O2的成功率，并确定了在医学、身体和/或精神方面存在缺陷的人群中成功的预测因素。在282次镇静过程中，对143名不合作患者（平均年龄6.4岁）的行为进行了评估。采用简化成功指数对结果进行评级：1-失败，2-中度成功；3-高度成功。研究了各种变量对镇静结果的影响：医学诊断的身体和/或神经学成分；以前的住院经历；药物类别。服用具有中枢神经系统作用药物的儿童，其镇静达到中度成功（p = 0.008）或高度成功（p = 0.002）的可能性显著降低。医学诊断中具有神经学成分的儿童，其镇静达到高度成功的可能性显著降低（p = 0.001）。口服镇静对该人群有效（77%成功），患者病情的某些特征可以预测成功。
