Escoubet B, Amsallem P, Ferrary E, Tran Ba Huy P
Prostaglandins. 1985 Apr;29(4):589-99. doi: 10.1016/0090-6980(85)90082-6.
This study describes the synthesis of prostaglandins (PGs) by the vascular structures of the inner ear (lateral wall = stria vascularis and spiral ligament) in vitro. The main PGs produced were PGI2, PGF2 alpha and PGE2. PGI2 and PGF2 alpha were also found in the perilymph. A 350 mg/kg ip injection of aspirin decreased PG synthesis by the lateral wall and PG levels in perilymph. This effect was reversed after 3 days. Gentamicin (10(-9) to 10(-5) M) decreased significantly and reversibly PG synthesis in vitro, as did 100 mg/kg ip injection. Acoustic stimulation increased ex vivo PGI2 and PGE2 synthesis without modifying PG levels in perilymph. Results suggest that PGs could be one humoral mediator of the cochlear microcirculation homeostasis, and, possibly, of the circulatory disturbances reported after acoustic stimulation. The decreased PG synthesis after gentamicin treatment could account for the angiotoxic component observed in aminoglycoside ototoxicity.
本研究描述了内耳血管结构（外侧壁=血管纹和螺旋韧带）在体外合成前列腺素（PGs）的情况。产生的主要PGs为前列环素（PGI2）、前列腺素F2α（PGF2α）和前列腺素E2（PGE2）。在内淋巴中也发现了PGI2和PGF2α。腹腔注射350mg/kg阿司匹林可降低外侧壁的PG合成以及内淋巴中的PG水平。3天后这种作用逆转。庆大霉素（10^(-9)至10^(-5)M）在体外可显著且可逆地降低PG合成，腹腔注射100mg/kg也有此作用。声刺激可增加离体PGI2和PGE2的合成，但不改变内淋巴中的PG水平。结果表明，PGs可能是耳蜗微循环稳态的一种体液介质，也可能是声刺激后所报道的循环紊乱的介质。庆大霉素治疗后PG合成减少可能是氨基糖苷类耳毒性中观察到的血管毒性成分的原因。
