Tatsumura T, Koyama S, Tsujimoto M, Kitagawa M, Kagamimori S
Department of Emergency, Toyama Medical and Pharmaceutical University, School of Medicine, Japan.
Br J Cancer. 1993 Dec;68(6):1146-9. doi: 10.1038/bjc.1993.495.
Nebulisation chemotherapy, a chemotherapeutic method for the treatment of lung cancer that involves the administration of anticancer agents through the inhalation of nebulised aerosols, has been found to be highly effective (Tatsumura et al., 1983a,b). We confirmed that 5-FU administered by this method accumulates in the trachea, bronchi and regional lymph nodes of patients treated before surgery, along with 5-FU metabolites, FUR and FUdR, indicating that 5-FU is directly incorporated and metabolised in the respiratory tract. Parallel result were obtained using mongrel dogs. The 5-FU levels in other organs, such as the heart and liver, were found to be extremely low. Only a trace of 5-FU was found in the serum of both the patients and the dogs. We further investigated the anti-tumour effect of this therapy in ten selected patients and observed a satisfactory anti-tumour response of 60.0%. These results, along with our previous finding that the retention time of isotope tracers inhaled as aerosol is considerably longer in tumour tissues than in normal parts (Tatsumura et al., 1983a) explain the high antitumour action of this therapy and the absence of adverse effects of administered 5-FU.
雾化化疗是一种治疗肺癌的化疗方法，通过吸入雾化气雾剂来给药抗癌药物，已被发现具有高效性（立村等人，1983年a、b）。我们证实，用这种方法给药的5-氟尿嘧啶（5-FU）与5-FU代谢产物氟脲嘧啶核苷（FUR）和氟脱氧尿苷（FUdR）一起，在手术前接受治疗的患者的气管、支气管和区域淋巴结中蓄积，这表明5-FU在呼吸道中直接被摄取并代谢。用杂种狗也得到了类似的结果。在心脏和肝脏等其他器官中发现的5-FU水平极低。在患者和狗的血清中仅发现微量的5-FU。我们进一步研究了这种疗法对十名选定患者的抗肿瘤作用，观察到令人满意的60.0%的抗肿瘤反应。这些结果，连同我们之前的发现，即作为气雾剂吸入的同位素示踪剂在肿瘤组织中的滞留时间比在正常部位长得多（立村等人，1983年a），解释了这种疗法的高抗肿瘤作用以及所给药的5-FU没有不良反应的原因。
