Neubauer R H, Rabin H, Brown A M
J Gen Virol. 1978 Nov;41(2):295-301. doi: 10.1099/0022-1317-41-2-295.
Comparisons of early antigens (EA) of EBV-related lymphotropic herpes virus of Old World primates have proved difficult to accomplish because antigen levels are low in infected cells and the ratio of virus capsid antigen to EA is generally high. To overcome these difficulties, we have developed a procedure which combines antigen stimulation with inhibition of late virus functions and results in the selective stimulation of EA. Using this procedure, we have examined the EA of EBV, herpesvirus papio, h. pongo, and h. pan. The results show that the EA of these viruses are composed of both R (restricted) and D (diffuse) components and that the EA, while related, are distinguishable.
对旧世界灵长类动物中与EB病毒相关的嗜淋巴细胞疱疹病毒的早期抗原（EA）进行比较已证明难以实现，因为感染细胞中的抗原水平较低，且病毒衣壳抗原与EA的比例通常较高。为克服这些困难，我们开发了一种程序，该程序将抗原刺激与晚期病毒功能抑制相结合，从而实现对EA的选择性刺激。使用此程序，我们检测了EB病毒、狒狒疱疹病毒、猩猩疱疹病毒和黑猩猩疱疹病毒的EA。结果表明，这些病毒的EA均由R（受限）和D（弥散）成分组成，并且这些EA虽然相关，但可以区分。
