建立类淋巴母细胞系并分离出源自大猩猩的爱泼斯坦-巴尔相关病毒。
Establishment of a lymphoblastoid cell line and isolation of an Epstein-Barr-related virus of gorilla origin.
作者信息
Neubauer R H, Rabin H, Strnad B C, Nonoyama M, Nelson-Rees W A
出版信息
J Virol. 1979 Sep;31(3):845-8. doi: 10.1128/JVI.31.3.845-848.1979.
A B-lymphoid cell line was established from a normal gorilla. The cells contained Epstein-Barr virus-related antigens, and herpesvirus particles were demonstrated by electron microscopy. DNA-DNA reassociation kinétics revealed 30 to 40% hybridization to Epstein-Barr virus with 50 genomes per cell. Examination of the viral nuclear antigen with gorilla sera showed this to be a unique isolate termed Herpesvirus gorilla. H. gorilla transformed gibbon B-lymphocytes in vitro.
从一只正常大猩猩身上建立了一个B淋巴细胞系。这些细胞含有与爱泼斯坦-巴尔病毒相关的抗原，并且通过电子显微镜证实存在疱疹病毒颗粒。DNA-DNA重缔合动力学显示，每个细胞有50个基因组时，与爱泼斯坦-巴尔病毒的杂交率为30%至40%。用大猩猩血清检测病毒核抗原表明，这是一种独特的分离株，称为大猩猩疱疹病毒。大猩猩疱疹病毒在体外转化长臂猿B淋巴细胞。
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