Arnadottir M, Brattström L, Simonsen O, Thysell H, Hultberg B, Andersson A, Nilsson-Ehle P
Department of Nephrology, University Hospital, Lund, Sweden.
Clin Nephrol. 1993 Oct;40(4):236-40.
Pyridoxine and folic acid supplementation in dialysis patients is a matter of debate. This study was performed to estimate the effects of pharmacologic doses of these vitamins on serum lipid and plasma homocysteine concentrations, which are known to be high in dialysis patients. Both hemodialysis and continuous ambulatory peritoneal dialysis patients were included in the study. Pyridoxine supplementation had a mild but significant cholesterol-lowering effect (7%). Folic acid supplementation significantly lowered plasma homocysteine concentrations by a mean of 30%. There was a strong, inverse correlation between blood folate and plasma homocysteine concentrations. These results indicate that daily supplementation with pyridoxine 300 mg and folic acid 5 mg has a beneficial effect on the cardiovascular risk profile in dialysis patients.
透析患者补充吡哆醇和叶酸存在争议。本研究旨在评估这些维生素的药理剂量对血清脂质和血浆同型半胱氨酸浓度的影响，已知这些指标在透析患者中较高。血液透析和持续性非卧床腹膜透析患者均纳入本研究。补充吡哆醇有轻微但显著的降胆固醇作用（7%）。补充叶酸可使血浆同型半胱氨酸浓度平均显著降低30%。血液叶酸与血浆同型半胱氨酸浓度之间存在强烈的负相关。这些结果表明，每日补充300毫克吡哆醇和5毫克叶酸对透析患者的心血管风险状况有有益影响。
