van Rhijn J A, Traag W A, Heskamp H H
State Institute for Quality Control of Agricultural Products, Wageningen, Netherlands.
J Chromatogr. 1993 Sep 22;619(2):243-9. doi: 10.1016/0378-4347(93)80113-i.
To meet the requirements of the European Community for confirmatory analysis of clenbuterol using low-resolution mass spectrometry, usually two different techniques (i.e. electron impact and chemical ionization) have to be applied to confirm unambiguously its presence in extracts of urine. This paper describes the application of two different derivatives and the simultaneous analysis of these two different derivatives in one gas chromatographic-mass spectrometric analysis. With the proposed combination of techniques, Community requirements can more easily be met in only one analytical run. Examples of the analysis of some urine samples are presented, as well as data on linearity, repeatability and equivalence of the combined technique to separate determinations.
为满足欧洲共同体使用低分辨率质谱法对克伦特罗进行确证分析的要求，通常必须应用两种不同的技术（即电子轰击和化学电离）来明确确认其在尿液提取物中的存在。本文描述了两种不同衍生物的应用以及在一次气相色谱 - 质谱分析中对这两种不同衍生物的同时分析。通过所提出的技术组合，仅在一次分析运行中就能更轻松地满足共同体的要求。文中给出了一些尿液样本的分析示例，以及关于该组合技术的线性、重复性和与单独测定等效性的数据。
