Gala R R, Subramanian M G, Peters J A, Jaques S
Horm Res. 1976;7(2):118-28. doi: 10.1159/000178719.
The influence of varying doses of perphenazine, thyrotropin-releasing hormone (TRH) and serotonin on prolactin release was examined in two species of monkeys: rhesus (Macaca mulatta) and crab-eating (Macaca fascicularis). The intravenous administration of 0.33 mg/kg body weight of perphenazine or 1.0 mug/kg body weight of TRH gave a greater release of prolactin than higher doses of perphenazine (1.0 mg/kg) or TRH) (3.4 mug/kg), respectively. Prolactin release induced by serotonin at doses of 1, 5 and 10 mug/kg was similar. Both atropine sulfate (Atr-SO4) and atropine methyl nitrate (Atr-MN) at a similar base level potentiated the prolactin releasing action of the high dose of perphenazine suggesting that high doses of perphenazine activate a cholinergic inhibitory component present in the pituitary. Atropine sulfate had no potentiating action on the TRH-induced prolactin release, while Atr-MN appeared to prolong the response of TRH without potentiating it. Neither form of atropine had any influence on serotonin-induced prolactin release. The data indicated that the lower prolactin response to high doses of perphenazine and TRH were brought about by different mechanisms, and that the mechanism for perphenazine appeared to be mediated through a pituitary cholinergic system.
在两种猴子——恒河猴（猕猴）和食蟹猴中，研究了不同剂量的奋乃静、促甲状腺激素释放激素（TRH）和血清素对催乳素释放的影响。静脉注射0.33毫克/千克体重的奋乃静或1.0微克/千克体重的TRH，分别比更高剂量的奋乃静（1.0毫克/千克）或TRH（3.4微克/千克）引起更大的催乳素释放。血清素在1、5和10微克/千克剂量下诱导的催乳素释放相似。在相似的基础水平上，硫酸阿托品（Atr-SO4）和硝酸甲基阿托品（Atr-MN）都增强了高剂量奋乃静的催乳素释放作用，这表明高剂量的奋乃静激活了垂体中存在的胆碱能抑制成分。硫酸阿托品对TRH诱导的催乳素释放没有增强作用，而Atr-MN似乎延长了TRH的反应，但没有增强它。两种形式的阿托品对血清素诱导的催乳素释放均无影响。数据表明，对高剂量奋乃静和TRH的较低催乳素反应是由不同机制引起的，并且奋乃静的机制似乎是通过垂体胆碱能系统介导的。
