Gala R R, Jaques S
Endocr Res Commun. 1975;2(1):95-108. doi: 10.3109/07435807509053841.
The influence of apomorphine and 2 Br-alpha-ergocryptine (CB-154) on drug-induced prolactin secretion was examined in an intact and an ovariectomized monkey (Macaca fascicularis). Perphenazine administered iv at one mg/kg BW induced a rapid and marked increase in serum prolactin. Apomorphine at a concentration of 4 mg/kg BW administered prior to perphenazine delayed the perphenazine-induced prolactin rise. The iv administration of CB-154 at either 200 or 2000 mu-g/kg BW completely blocked the perphenazine response. Apomorphine injected before TRH suppressed the induced prolactin increase to this releasing hormone while CB-154, even at the very high dose, only partially blocked the TRH-induced prolactin rise. Serotonin injected iv at the level of 10 mg/kg BW induced a rapid and marked increase in serum prolactin and both apomorphine and CB-154 were able to block this response.
在完整和去卵巢的食蟹猴（猕猴属）中研究了阿扑吗啡和2-溴-α-麦角隐亭（CB-154）对药物诱导的催乳素分泌的影响。静脉注射1mg/kg体重的奋乃静可导致血清催乳素迅速且显著升高。在注射奋乃静之前给予浓度为4mg/kg体重的阿扑吗啡可延迟奋乃静诱导的催乳素升高。静脉注射200或2000μg/kg体重的CB-154可完全阻断奋乃静反应。在促甲状腺激素释放激素（TRH）之前注射阿扑吗啡可抑制该释放激素诱导的催乳素升高，而CB-154即使在非常高的剂量下也只能部分阻断TRH诱导的催乳素升高。静脉注射10mg/kg体重的血清素可导致血清催乳素迅速且显著升高，阿扑吗啡和CB-154均能够阻断该反应。
