Sinniah M, Ooi B G
Division of Virology Institute, Medical Research, Kuala Lumpur, Malaysia.
Singapore Med J. 1993 Apr;34(2):132-4.
We studied the presence of Hepatitis C Virus (HCV) antibodies in a defined Malaysian population and examined the association, if any, between HCV and the Hepatitis B Virus (HBV), using sensitive recombinant DNA second generation Enzyme Immunoassay (EIA) test kits. This sero-prevalence study comprised 1,434 sera from eleven distinct groups comprising intravenous drug users (IVDU), haemophiliacs, male homosexuals, female prostitutes, healthy blood donors, staff of dialysis unit and laboratory personnel, chronic renal failure patients undergoing dialysis (CRFD), patients with liver cirrhosis, chronic active hepatitis, chronic persistent hepatitis and primary liver cancer. Except in laboratory personnel and dialysis staff, HCV antibodies were detected in each group of patients ranging from 3% in blood donors to 85% in IVDU. The main modes of HCV transmission identified were parenteral drug use, transfusion and/or dialysis related. The HBV was found to be the major viral etiological agent in 75% of chronic liver disease (CLD); while in 10% of cases both HCV and HBV were detected. HCV was implicated as the sole viral agent in only a small proportion (1.5%) of patients with chronic liver disease.
我们在特定的马来西亚人群中研究了丙型肝炎病毒（HCV）抗体的存在情况，并使用灵敏的重组DNA第二代酶免疫测定（EIA）试剂盒检测了HCV与乙型肝炎病毒（HBV）之间是否存在关联。这项血清流行率研究纳入了来自11个不同群体的1434份血清，这些群体包括静脉吸毒者（IVDU）、血友病患者、男性同性恋者、女性妓女、健康献血者、透析科室工作人员和实验室人员、接受透析的慢性肾衰竭患者（CRFD）、肝硬化患者、慢性活动性肝炎患者、慢性持续性肝炎患者和原发性肝癌患者。除了实验室人员和透析工作人员外，在每组患者中均检测到了HCV抗体，献血者中的检出率为3%，IVDU中的检出率为85%。确定的HCV主要传播途径为注射吸毒、输血和/或与透析相关。在75%的慢性肝病（CLD）中，HBV被发现是主要的病毒病原体；而在10%的病例中，同时检测到了HCV和HBV。在仅一小部分（1.5%）慢性肝病患者中，HCV被认为是唯一的病毒病原体。
