来自俄罗斯的两株普马拉病毒分离株M和S基因组片段的核苷酸及推导的氨基酸序列
Nucleotide and deduced amino acid sequences of the M and S genome segments of two Puumala virus isolates from Russia.
作者信息
Xiao S Y, Spik K W, Li D, Schmaljohn C S
机构信息
Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702.
出版信息
Virus Res. 1993 Oct;30(1):97-103. doi: 10.1016/0168-1702(93)90019-j.
Hemorrhagic fever with renal syndrome (HFRS) is caused by viruses in the Hantavirus genus, family Bunyaviridae. Three serologically distinct hantaviruses, Hantaan, Seoul and Puumala viruses, are known to cause HFRS. We report here, for the first time, gene sequences of two human Puumala virus isolates, P360 and K27, obtained in an HFRS endemic region of the former Soviet Union. We compared the nucleotide sequences and the derived amino acid sequences of their gene products to a Puumala virus isolate from rodents.
肾综合征出血热（HFRS）由布尼亚病毒科汉坦病毒属的病毒引起。已知三种血清学上不同的汉坦病毒，即汉滩病毒、汉城病毒和普马拉病毒，可引起肾综合征出血热。我们在此首次报告在前苏联肾综合征出血热流行地区获得的两株人类普马拉病毒分离株P360和K27的基因序列。我们将其基因产物的核苷酸序列和推导的氨基酸序列与一株来自啮齿动物的普马拉病毒分离株进行了比较。
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