一种新发现的与路易斯安那州一例汉坦病毒肺综合征致死病例相关的病毒。
A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana.
作者信息
Morzunov S P, Feldmann H, Spiropoulou C F, Semenova V A, Rollin P E, Ksiazek T G, Peters C J, Nichol S T
机构信息
Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
出版信息
J Virol. 1995 Mar;69(3):1980-3. doi: 10.1128/JVI.69.3.1980-1983.1995.
Abstract
Genetic analysis of virus detected in autopsy tissues of a fatal hantavirus pulmonary syndrome-like case in Louisiana revealed the presence of a previously unrecognized hantavirus. Nucleotide sequence analysis of PCR fragments of the complete S and M segments of the virus amplified from RNA extracted from the tissues showed the virus to be novel, differing from the closest related hantavirus, Sin Nombre virus, by approximately 30%. Both genome segments were unique, and there was no evidence of genetic reassortment with previously characterized hantaviruses. The primary rodent reservoir of Sin Nombre virus, the deer mouse Peromyscus maniculatus, is absent from Louisiana. Thus, the virus detected in Louisiana, referred to here as Bayou virus, must possess a different rodent reservoir.
摘要
对路易斯安那州一例类似汉坦病毒肺综合征致死病例尸检组织中检测到的病毒进行基因分析，结果显示存在一种此前未被识别的汉坦病毒。从组织中提取的RNA扩增出的病毒完整S和M片段的PCR产物进行核苷酸序列分析，结果表明该病毒是新病毒，与亲缘关系最近的汉坦病毒——辛诺柏病毒相比，差异约为30%。两个基因组片段均是独特的，没有证据表明它与先前鉴定的汉坦病毒发生了基因重配。路易斯安那州没有辛诺柏病毒的主要啮齿动物宿主——白足鼠（鹿鼠）。因此，在路易斯安那州检测到的这种病毒（此处称为河口病毒）必定有不同的啮齿动物宿主。
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本文引用的文献
1
RNA binding of recombinant nucleocapsid proteins of hantaviruses.汉坦病毒重组核衣壳蛋白的RNA结合
Virology. 1993 May;194(1):332-7. doi: 10.1006/viro.1993.1263.
2
Canine distemper virus L gene: sequence and comparison with related viruses.犬瘟热病毒L基因：序列及与相关病毒的比较。
Virology. 1993 Mar;193(1):50-65. doi: 10.1006/viro.1993.1102.
3
Nucleotide and deduced amino acid sequences of the M and S genome segments of two Puumala virus isolates from Russia.来自俄罗斯的两株普马拉病毒分离株M和S基因组片段的核苷酸及推导的氨基酸序列
Virus Res. 1993 Oct;30(1):97-103. doi: 10.1016/0168-1702(93)90019-j.
4
Phylogenetic analyses of virus isolates in the genus Hantavirus, family Bunyaviridae.布尼亚病毒科汉坦病毒属病毒分离株的系统发育分析。
Virology. 1994 Jan;198(1):205-17. doi: 10.1006/viro.1994.1023.
5
Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness.与急性呼吸道疾病暴发相关的汉坦病毒的基因鉴定。
Science. 1993 Nov 5;262(5135):914-7. doi: 10.1126/science.8235615.
6
Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States.将鹿鼠鉴定为美国西南部一种新型汉坦病毒的主要啮齿类宿主的血清学和遗传学方法
J Infect Dis. 1994 Jun;169(6):1271-80. doi: 10.1093/infdis/169.6.1271.
7
Genome structure and variability of a virus causing hantavirus pulmonary syndrome.引起汉坦病毒肺综合征的一种病毒的基因组结构与变异性
Virology. 1994 May 1;200(2):715-23. doi: 10.1006/viro.1994.1235.
8
Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The Hantavirus Study Group.汉坦病毒肺综合征：17例新发现疾病患者的临床描述。汉坦病毒研究小组。
N Engl J Med. 1994 Apr 7;330(14):949-55. doi: 10.1056/NEJM199404073301401.
9
Sequences of wild Puumala virus genes show a correlation of genetic variation with geographic origin of the strains.
J Gen Virol. 1994 Feb;75 ( Pt 2):405-9. doi: 10.1099/0022-1317-75-2-405.
10
Isolation of the causative agent of hantavirus pulmonary syndrome.汉坦病毒肺综合征病原体的分离
Am J Trop Med Hyg. 1994 Jul;51(1):102-8. doi: 10.4269/ajtmh.1994.51.102.
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