Kato M, Matsuda T, Kotoh K, Kaneko M, Imagawa H, Ueda T, Kuratani T, Yoshioka Y, Ohnishi K
Division of Cardiovascular Surgery, Osaka Prefectural Hospital, Japan.
ASAIO J. 1993 Jul-Sep;39(3):M518-21.
The authors developed a new intraluminal aortic prosthesis (IA graft) for internal obliteration of Stanford type B dissection. The newly devised intraluminal aortic graft is a self-expandable metallic stent (Gianturco stent) outer-jacketed with a thin open-cell structured microporous film made of segmental polyurethane (0.2 mm thick, 0.1 mm pore size). Through the femoral artery, the intraluminal aortic grafts (14-20 mm diameter-, 4 cm long) were inserted into a 12 Fr catheter sheath by compression, were implanted into the descending thoracic aortas of five mongrel dogs; they were removed at the projected times of death ranging from 1 to 6 months after implantation. Histopathologic examination revealed that an elastic fiber layer had regenerated and that on the inner surface of the graft adherent and proliferating endothelial cells were observed, even at 1 month after graft implantation. Complete epithelialization was observed over the entire inner surface of the graft within 4 months after implantation. This healing process suggests that the intraluminal aortic graft is highly biocompatible and might be stable in chronic use after the obliteration of acute Stanford type B dissections.
作者研发了一种用于斯坦福B型夹层内闭塞的新型腔内主动脉假体（IA移植物）。新设计的腔内主动脉移植物是一种自膨胀金属支架（朱尔科支架），外部套有一层由分段聚氨酯制成的薄开孔结构微孔膜（厚0.2毫米，孔径0.1毫米）。通过股动脉，将腔内主动脉移植物（直径14 - 20毫米，长4厘米）经压缩后插入12F导管鞘中，植入5只杂种犬的降主动脉；在植入后1至6个月的预计死亡时间将其取出。组织病理学检查显示，即使在移植物植入后1个月，弹性纤维层也已再生，并且在移植物内表面观察到有黏附并增殖的内皮细胞。植入后4个月内，在移植物的整个内表面观察到完全上皮化。这一愈合过程表明，腔内主动脉移植物具有高度生物相容性，在急性斯坦福B型夹层闭塞后长期使用可能是稳定的。
