Liu T, Soong S J, Wilson N P, Craig C B, Cole P, Macaluso M, Butterworth C E
Biostatistics Unit, University of Alabama at Birmingham 35294.
Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec;2(6):525-30.
The association of nutritional factors with cervical dysplasia was examined through a case-control study. Analysis was conducted in 257 cases and 133 controls confirmed both by cytological examination and colposcopic findings. A 24-h dietary recall questionnaire was used to assess nutritional intake. Various risk factors (including age at first intercourse, number of sexual partners, parity, cigarette smoking, oral contraceptive use, human papillomavirus type 16 infection, and age and race) were adjusted for their potential confounding effects. While analyses were also performed to adjust for total calories, results were not changed significantly. Among the nutrients examined, vitamin A intake showed a significantly increased risk at the lowest quartile compared to the highest quartile, with an odds ratio of 2.2 (95% confidence interval, 1.2-4.2). A significant trend of increasing risk was also observed with lower intake of vitamin A (P = 0.05). Riboflavin showed increased risk at the two lower quartiles of intake with a trend test P value of 0.04. Increased risk was also found for lower intakes of vitamin C compared to the highest intake level. For folate, increased risk was found in the second highest quartile compared with the highest quartile with an odds ratio of 2.0 (95% confidence interval, 1.0-3.8). The calcium:phosphorus ratio showed an increased risk at the lowest level (odds ratio, 2.0; 95% confidence interval, 1.0-4.3). Insufficient intake of vitamin A, riboflavin, ascorbate, and folate is associated with an increased risk of cervical dysplasia.
通过一项病例对照研究，对营养因素与宫颈发育异常的关联进行了检查。对257例病例和133例对照进行了分析，这些病例和对照均经细胞学检查和阴道镜检查结果确诊。采用24小时饮食回顾问卷来评估营养摄入量。对各种危险因素（包括初次性交年龄、性伴侣数量、产次、吸烟、口服避孕药使用、16型人乳头瘤病毒感染以及年龄和种族）的潜在混杂效应进行了调整。虽然也进行了分析以调整总热量，但结果没有显著变化。在所检查的营养素中，与最高四分位数相比，维生素A摄入量在最低四分位数时显示出风险显著增加，优势比为2.2（95%置信区间，1.2 - 4.2）。维生素A摄入量较低时也观察到风险增加的显著趋势（P = 0.05）。核黄素在摄入量较低的两个四分位数时显示出风险增加，趋势检验P值为0.04。与最高摄入量水平相比，维生素C摄入量较低时也发现风险增加。对于叶酸，与最高四分位数相比，第二高四分位数时发现风险增加，优势比为2.0（95%置信区间，1.0 - 3.8）。钙磷比在最低水平时显示出风险增加（优势比，2.0；95%置信区间，1.0 - 4.3）。维生素A、核黄素、抗坏血酸和叶酸摄入不足与宫颈发育异常风险增加有关。
