Zurgil N, Bakimer R, Tincani A, Faden D, Cohen J, Lorber M, Valesini G, Shoenfeld Y
Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.
Lupus. 1993 Aug;2(4):233-7. doi: 10.1177/096120339300200405.
The titers, isotypes and idiotypes of antiphospholipid and anti-dsDNA antibodies were determined in seven pairs of mothers with antiphospholipid syndrome (APLS) and their offspring, in 11 pairs of SLE mothers and their matched infants and in seven respective pairs of healthy subjects. In addition, maternal as well as fetal sera were evaluated for the presence of anti-SSA (Ro), anti-SSB (La) and anti-70 kd RNP autoantibodies. In the sera from APLS patients, as well as in the sera from their offspring, the mean antibody titer of IgG aCL was found to be significantly higher then the corresponding value in the control group (P < 0.01). Highly significant increased titers of IgG anti-DNA antibodies were found in the sera of SLE mothers and their matched offspring (P < 0.0008). The prevalence of anti-SSA, anti-SSA, and anti-70Kd RNP antibodies was lower then that of antiphospholipid and anti-dsDNA antibodies. Only one of the respective offspring had increased levels of these antibodies. The quantity of maternal antibodies transferred to the fetus was depended on their concentration in the maternal circulation, as well as on their type and specificity. Follow-up of newborn sera showed a progressive decrease in the antiphospholipid antibody titers during 3 months. After 6 months it was undetected. Our results point to a transplacental transfer of aCL and anti-DNA antibodies, a phenomenon which is not necessarily associated with respective clinical manifestations, in contrast to the classical humoral mediated autoimmune diseases (e.g. myasthenia gravis).
在7对患有抗磷脂综合征（APLS）的母亲及其后代、11对系统性红斑狼疮（SLE）母亲及其匹配的婴儿以及7对健康受试者中，测定了抗磷脂和抗双链DNA抗体的滴度、亚型和独特型。此外，还评估了母血和胎儿血清中抗SSA（Ro）、抗SSB（La）和抗70kd核糖核蛋白自身抗体的存在情况。在APLS患者及其后代的血清中，发现IgG抗心磷脂（aCL）抗体的平均滴度显著高于对照组的相应值（P<0.01）。在SLE母亲及其匹配后代的血清中，发现IgG抗DNA抗体滴度显著升高（P<0.0008）。抗SSA、抗SSB和抗70Kd核糖核蛋白抗体的患病率低于抗磷脂和抗双链DNA抗体。各自的后代中只有一人这些抗体水平升高。转移到胎儿体内的母体抗体数量取决于它们在母体循环中的浓度，以及它们的类型和特异性。对新生儿血清的随访显示，抗磷脂抗体滴度在3个月内逐渐下降。6个月后未检测到。我们的结果表明aCL和抗DNA抗体可经胎盘转移，这一现象不一定与相应的临床表现相关，这与经典的体液介导的自身免疫性疾病（如重症肌无力）不同。
