Ballhause H, Kähling J
Psychopharmacology (Berl). 1976 Nov 24;50(3):281-3. doi: 10.1007/BF00426845.
A runway apparatus for rats has been developed for measuring motor incoordination and running time. Animals were trained to run along an elevated narrow pathway. Frequency and severity of slipping off and running time were automatically counted. Rats were given diazepam, phenobarbital or chlorpromazine orally and tested 1 h later. Diazepam, 8-64 mg/kg p.o., caused slipping off in a dose-dependent manner. Phenobarbital had a similar effect with 64 mg/kg p.o. Chlorpromazine, 32 and 64 mg/kg p.o., caused other signs of motor deficit.
已开发出一种用于大鼠的跑道装置，用于测量运动不协调和奔跑时间。训练动物沿着高架狭窄通道奔跑。自动记录滑倒的频率和严重程度以及奔跑时间。给大鼠口服地西泮、苯巴比妥或氯丙嗪，1小时后进行测试。口服8 - 64毫克/千克的地西泮会导致滑倒，且呈剂量依赖性。口服64毫克/千克的苯巴比妥有类似效果。口服32和64毫克/千克的氯丙嗪会导致其他运动缺陷迹象。
