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DRL在区分中枢神经系统药物的抗焦虑和抗精神病特性中的应用。

Use of DRL in differentiating anxiolytic and neuroleptic properties of CNS drugs.

作者信息

Canon J G, Lippa A S

出版信息

Pharmacol Biochem Behav. 1977 May;6(5):591-3. doi: 10.1016/0091-3057(77)90122-8.

DOI:10.1016/0091-3057(77)90122-8
PMID:19772
Abstract

Presented in this paper are the effects of chlorpromazine, clozapine, d-amphetamine and diazepam on DRL behavior in rats. D-Amphetamine and diazepam, which showed similar effects on response errors, could be identified on the basis of burst responding and drug interaction. Clozapine, a new antipsychotic agent which does not cause extrapyramidal side effect in man affected DRL behavior in the same way as did chlorpromazine. Thus, DRL schedules are probably not useful in differentiating various neuroleptic agents.

摘要

本文介绍了氯丙嗪、氯氮平、右旋苯丙胺和地西泮对大鼠DRL行为的影响。右旋苯丙胺和地西泮对反应错误表现出相似的影响，可根据爆发反应和药物相互作用来鉴别。氯氮平是一种新型抗精神病药物，在人体中不会引起锥体外系副作用，它对DRL行为的影响与氯丙嗪相同。因此，DRL程序可能无助于区分各种抗精神病药物。

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