Wand R R, Matazow G S, Shady G A, Furer P, Staley D
Department of Psychiatry, St. Boniface General Hospital, Winnipeg, Manitoba, Canada.
Neurosci Biobehav Rev. 1993 Fall;17(3):271-5. doi: 10.1016/s0149-7634(05)80010-7.
Four hundred forty-six patients with Tourette Syndrome (TS) and/or their parents completed a 52-item self-report survey about vocal and motor tics, and the frequency of associated co-morbid conditions of aggression, obsessions and compulsions, attentional problems, sleep disturbance, mood disturbance, anxiety, and self-mutilative behaviours which have been frequently reported in the literature on TS. Respondents also responded to an open-ended question regarding the most disabling aspects of TS. Results were analyzed within two age groups; under 18 years of age (N = 245) and 18 years of age or older (N = 177). Tics and associated conditions were the most frequently reported disabling aspect by both age groups. Subjects under age 18, however, reported significantly more frequent problems with hyperactivity, temper control, aggressive behaviours and sleepwalking than adults with TS.
446名患有妥瑞氏症（TS）的患者及其父母完成了一项关于发声和运动抽动以及攻击、强迫观念和强迫行为、注意力问题、睡眠障碍、情绪障碍、焦虑和自残行为等相关共病状况发生频率的52项自我报告调查，这些共病状况在关于妥瑞氏症的文献中经常被报道。受访者还回答了一个关于妥瑞氏症最具致残性方面的开放性问题。在两个年龄组中对结果进行了分析；18岁以下（N = 245）和18岁及以上（N = 177）。抽动及相关状况是两个年龄组报告的最常见的致残方面。然而，18岁以下的受试者报告的多动、情绪控制、攻击行为和梦游问题比成年妥瑞氏症患者更频繁。
