Mace S E, Newman A J, Liebman J
Am J Dis Child. 1984 Nov;138(11):1067-70. doi: 10.1001/archpedi.1984.02140490067017.
The serum uric acid levels and uric acid clearance rates were evaluated in 28 patients who had congenital heart disease. Based on hemodynamic assessments, the patients were divided into three groups: group 1, with normal cardiac output and normal arterial oxygen saturation; group 2, with hypoxemia (normal cardiac output with a decreased arterial oxygen saturation); and group 3, with cardiomyopathy (decreased cardiac output). The blood levels of uric acid were elevated in group 3. The mean serum uric acid levels were as follows: group 1, 4.2 mg/dL; group 2, 4.8 mg/dL; and group 3, 11.7 mg/dL. All the patients in groups 2 and 3 had decreased uric acid clearance rates. The mean uric acid clearance rates were as follows: group 1, 10.1 mL/min/sq m; group 2, 4.2 mL/min/sq m; and group 3, 1.7 mL/min/sq m. The patients in group 3 had the most severe abnormalities. Patients with congenital heart disease may have marked impairment of their uric acid excretion, which can occur in the absence of significant renal disease, and may be found in acyanotic as well as cyanotic patients.
对28例先天性心脏病患者的血清尿酸水平和尿酸清除率进行了评估。根据血流动力学评估，将患者分为三组：第1组，心输出量正常且动脉血氧饱和度正常；第2组，低氧血症（心输出量正常但动脉血氧饱和度降低）；第3组，心肌病（心输出量降低）。第3组患者的血尿酸水平升高。平均血清尿酸水平如下：第1组，4.2mg/dL；第2组，4.8mg/dL；第3组，11.7mg/dL。第2组和第3组的所有患者尿酸清除率均降低。平均尿酸清除率如下：第1组，10.1mL/min/平方米；第2组，4.2mL/min/平方米；第3组，1.7mL/min/平方米。第3组患者的异常情况最为严重。先天性心脏病患者的尿酸排泄可能有明显受损，这可能在无明显肾脏疾病的情况下发生，并且在无青紫型和青紫型患者中均可发现。
