Jansson L, Wahlberg J, Andersson A
Department of Medical Cell Biology, Uppsala University, Sweden.
Eur Surg Res. 1993;25(6):383-9. doi: 10.1159/000129305.
Syngeneic pancreaticoduodenal transplantations were performed in Wistar-Furth rats. Fourteen days after implantation, blood perfusion of the whole native and transplanted pancreas, the pancreatic islets and the native and transplanted duodenum was measured with a microsphere technique 5 min after an intravenous injection of 0.5 ml of either saline (n = 6) or terbutaline (1 mg/kg BW; n = 9). Terbutaline decreased the mean arterial blood pressure by approximately 30% (p < 0.001). The substance also decreased the whole pancreatic blood flow of the native pancreas (p < 0.05), but not of the transplanted gland. However, the vascular conductance of the whole pancreas was unchanged after terbutaline administration in both the native and transplanted gland. Islet blood flow (p < 0.001) and islet vascular conductance (p < 0.01) were markedly decreased in the native pancreas. In the transplanted gland, there was, however, no change in islet vascular conductance and only a slight decrease in islet blood flow (p < 0.05). Both the native and transplanted duodenal blood flows were unaffected by terbutaline. One likely explanation for the different effects of terbutaline on the blood perfusion of the native and transplanted pancreas may be that the latter gland is devoid of any physiologically relevant exogenous innervation.
在Wistar-Furth大鼠中进行了同基因胰十二指肠移植。植入后14天，在静脉注射0.5 ml生理盐水（n = 6）或特布他林（1 mg/kg体重；n = 9）5分钟后，用微球技术测量整个天然胰腺和移植胰腺、胰岛以及天然和移植十二指肠的血液灌注。特布他林使平均动脉血压降低约30%（p < 0.001）。该物质还降低了天然胰腺的全胰腺血流量（p < 0.05），但对移植胰腺的血流量没有影响。然而，在给予特布他林后，天然胰腺和移植胰腺的全胰腺血管传导率均未改变。天然胰腺的胰岛血流量（p < 0.001）和胰岛血管传导率（p < 0.01）显著降低。然而，在移植胰腺中，胰岛血管传导率没有变化，只有胰岛血流量略有降低（p < 0.05）。特布他林对天然胰腺和移植胰腺血液灌注的不同影响的一个可能解释是，移植胰腺缺乏任何生理相关的外源性神经支配。
